Study of the effect of the aqueous extract of Beta vulgaris root on the cancerous cell line A549 and the normal cell line REF

Abstract

The study included studying the cytotoxic effect of the aqueous extract of beet roots "Beta
vulgaris" on the lung cancer cell line A549,using six diluted concentrations of the aqueous extract of
the plant roots (7,8 , 31,25 , 62,5 , 125 , 250 , 500 ) (μg/ml) and for three periods of exposure
(24,48,72) hours.The quantitative estimation of the active compounds of the aqueous extract of the
plant was calculated,as it was found that the aqueous extract of beet roots contains many active
compounds,they are (Saponins- Tannins - Phenols - Flavonoids - Glycosides).
The study showed that the concentration causing inhibition of normal cell proliferation REF by the
aqueous extract of the plant 50% ( Ic50) was 6.35 mg/ml.The aqueous extract of beet roots was tested
to detect the cytotoxic effect of the aqueous extract and all concentrations used on the lung cancer
cell line A49.An increase in the percentage of cancer cell growth inhibition has been observed for all
exposure periods (24,48,72) hours,with significant differences at the probability level (p≤0.05) and
compared with the control,where the percentage rate of inhibition at the lowest concentration ranges
(μg/ml 7.8) (4.661±1.864), (5.640±2.743), (6.584±4.159) respectively,and the rate of inhibition
increased at the concentration (μg/ml 500) (90.250±1.409) (92.743±1.252) and (94.738±1.416)
respectively