Study of the effect of the aqueous extract of the roots of (Beta vulgaris) on the cancer cell line A549 and the normal cell line REF

Abstract

     The study included  studying the cytotoxic effect of the aqueous extract of beet roots (Beta vulgaris) on the lung cancer cell line A549،using six diluted   concentrations of the aqueous extract of the plant roots (7،8 ، 31،25 ، 62،5 ، 125 ، 250 ، 500 ) (µg/ml) and for three periods of exposure (24،48،72) hours. The quantitative estimation of the active compounds of the aqueous extract of the plant was calculated، as it was found that the aqueous extract of beet roots contains many active compounds، they are (Saponins- Tannins - Phenols - Flavonoids - Glycosides). The study showed that the concentration causing inhibition of normal cell proliferation REF by the aqueous extract of the plant 50% (Ic50) was 6.35 mg/ml. The aqueous extract of beet roots was tested to detect the cytotoxic effect of the aqueous extract and all concentrations used on the lung cancer cell line A49.An increase in the  percentage of cancer cell growth inhibition has been observed for all exposure periods (24،48،72) hours، with significant differences at the  probability level (p≤0.05) and compared with the control، where the percentage rate of inhibition  at the lowest concentration ranges (µg/ml 7.8) (4.661±1.864)، (5.640±2.743)، (6.584±4.159) respectively، and the rate of inhibition increased at the concentration (µg/ml 500) (90.250±1.409) (92.743±1.252) and (94.738±1.416) respectively .